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View Hanry's webinar on demand here!

Date:   26 October 2021 (Tuesday)

Time:   11am - 12pm

Format: Zoom Webinar (registration is required)

Hosted by: Xinyi  SU,
IMCB & ExCo SCSS


Speaker's information

Hanry YU
Singapore-MIT Alliance for Research and Technology, Singapore
"Engineering 3D Cellular Niche for Applications"

Picture
ABSTRACT

Stem cells exhibit significant changes in cell states as they differentiate. Spatio-temporal modulation of the cell interactions with soluble & matrix environment, and neighboring cells in 3D culture in differentiation can significantly impact the final cell phenotypes and applications. Using 3 examples, I would demonstrate simple controls of these interactions. In an organoid-on-chip model, cells differentiated in situ as perfused organoids yield better function than organoids formed from differentiated cells. In iPSC-derived cell model, human Kupffer cells were generated from co-culture with hepatocytes or conditioned media yield extremely high function similar to the best primary human Kupffer cells. Finally, adult liver stem cells in a classical collagen sandwich model exhibit extra-ordinary cellular dynamics forming bile duct-like long tube structures that display events similar to bile duct development. Principles of controlling 3D cellular niche will be discussed, and if time permits, progress in SMART CAMP will be introduced.​

BIO
Hanry Yu is Professor of Physiology (NUSMed) and Mechanobiology (MBI) at the National University of Singapore; and leads a Cell and Tissue Engineering group at the Institute of Bioengineering and Bioimaging (IBB), A*STAR; and co-leads a cell therapy manufacturing programme (CAMP) at the MIT research entity (SMART) in Singapore. He integrates biomaterials, tissue mechanobiology and engineering, biomedical optics and AI data analytics into solutions for pharmaceutical, environmental, and recently food industries. He has trained many students and staffs in leading universities in the US and Asia; built several institutions and companies, published >200 papers, delivered >250 invited talks, and is serving as a handling editor for Biomaterials.

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  • Home
  • Our Society
    • Office Bearers & Exco
    • Cell Therapy Focus Group
  • SCSS Symposium 2022
    • Programme
    • Organizing Committee
    • Poster Guide 2022
    • Exhibition Hall 2022
    • Registration
    • Supporters 2022
  • Membership
  • Events
    • AGM 2022
    • Upcoming Events
    • Past SCSS Events
      • Past SCSS Symposia
        • SCSS Symposium 2021
          • Organizing Committee
          • Speakers
          • Programme
          • Supporters
        • SCSS-JSRM 2020
          • Supporters 2020
          • Organizing Committee 2020
        • SCSS-ISCT 2019
          • Supporters
        • EMBO Workshop 2018
        • SCSS Symposium 2017
        • SCSS Symposium 2016
        • Symposia before 2016
  • Resources
    • Awards
      • SCSS Dr. Susan Lim Award
    • Fellowships
      • Overseas Travel Fellowship Programme
      • SCSS Symposium Fellowships
    • Information on Stem Cells
    • Job Market
  • Contact