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Programme (7-9 December)
(updated on 4 Dec 22)


Day 1, 7 December 2022

9:00 – 9:10      Welcome and opening

                        Ray DUNN, President SCSS & Jonathan LOH, Chair of Organizing Committee

 

9:10 -9:45        Keynote lecture

Chair: Jonathan LOH, Institute of Molecular and Cell Biology, Singapore

 

The Piwi-piRNA pathway: a New World of gene regulation

Haifan LIN, Yale School of Medicine, US

 

 

9:45 - 11:10     Session 1a. Precision Medicine and Stem Cell Models I

                        Chair: Christine CHEUNG, LKCM, Singapore

 

9:45 - 10:10     Genome-scale CRISPR screening for LDLR-independent pathways regulating LDL uptake

Haojie YU, National University of Singapore

           

10:10 – 10:25  Selected Abstract

                        Characterization of LVV-transduced, in vitro-expanded anti-TIM3 CAR T cells

                        Wei-Xiang SIN, Singapore-MIT Alliance for Research and Technology (SMART), Singapore

 

10:25 – 10:45  Industry Talk

                        Leveraging genome editing of iPSCs to create disease models

                        Yu ZOU, Thermo Fisher Scientific, Singapore

 

10:45 – 11:10  Implications of cancer cell state plasticity for therapeutic intervention

Wai Leong TAM, Genome Institute of Singapore

 

11:10- 11:40    BREAK                       

 

11:40 – 12:45  Session 1b. Stem Cells, Ageing and Rejuvenation I

                        Chair: Li ZENG, National Neuroscience Institute, Singapore

 

11:40 – 12:05  Combining stem cell rejuvenation and senescence targeting to synergistically extend lifespan

Nicholas Stanislaw TOLWINSKI, Yale-NUS, Singapore

 

12:05 – 12:20  Selected Abstract

                        Telomerase reverse transcriptase (TERT) loss-of-function results in motor neuron and astrocyte ageing

                        Jasmine HARLEY, Institute of Molecular and Cell Biology, Singapore

 

12:20 – 12:45  Asian Immune Diversity Atlas (AIDA): Single cell analysis of human diversity

Kian Hong KOCK, Genome Institute of Singapore

 

12:45 – 13:45  LUNCH BREAK                      

 

13:45 – 16:55  Session 2. Young Investigators’ Forum

Chair: Natasha NG, Institute of Molecular and Cell Biology, Singapore

 

13:45 – 14:10  Keynote lecture

Human pluripotent stem cells, organoids and disease modelling

Shuibing CHEN, Cornell University, USA

                       

14:10 – 14:25  Selected Abstract

                        A stem cell-based toolkit to study deadly biosafety level 4 viruses

                        Lay Teng ANG, Stanford Institute for Stem Cell Biology & Regenerative Medicine, USA

 

14:25 – 14:40  Industry talk

Droplet Digital PCR provides high sensitivity in the detection of pluripotent stem cells

Kee Wah LEE, Bio-Rad Laboratories (Singapore) Pte Ltd

 

14:40 – 15:05  Integrative analysis of single-cell transcriptomics with multiplexed RNA imaging for mapping autism pathophysiology

Jinyue LIU, Genome Institute of Singapore

 

15:05– 15:35   BREAK                       

 

15:35 – 16:25  Panel discussion – “Stories about career transitions and the path to leadership in science”

                       

Panellists:

                       

Shi Yan NG, Principal Investigator, Institute of Molecular and Cell Biology, Singapore

 

Lisa OOI, Vice President (Strategy), Hummingbird Bioscience, Singapore

                       

Fong Ming KOH, LYFE Capital, Singapore

 

Ying Xim TAN, Medisix Therapeutics, Singapore

                       

16:25 – 16:50  iPSC-driven inflection point in the cell therapy industry

Koji TANABE, I Peace, Japan

Chair: Jonathan Loh, Institute of Molecular and Cell Biology, Singapore

 

 

16:50 – 18:30  YOUNG INVESTIGATORS’ FORUM NETWORKING & COCKTAIL RECEPTION

                        With a SPEED DATING segment!

                       

END OF DAY 1


Day 2, 8 December 2022

9:00 – 10:25    Session 3a. Stem Cells, Ageing and Rejuvenation II

Chair: Li ZENG, National Neuroscience Institute, Singapore

 

9:00 – 9:25      Interventional strategies to enhance longevity

Brian KENNEDY, National University of Singapore

 

9:25 – 9:45      Industry Talk

Enhancing survival: Novel methods for stem cell colony selection and retrieval

Darius Cameron WILSON, Sartorius Corporation

 

9:45 – 10:00    Selected Abstract

                        Cord lining induced pluripotent stem cell-derived retinal pigment epithelium (CLiPS-RPE): A novel source for cell therapy for age-related macular degeneration (AMD)

                        Mayuri BHARGAVA, Institute of Molecular and Cell Biology, Singapore

 

10:00 – 10:25  Communication between gut microbiota and organ function regulates Biological Ageing

Sven PETTERSON, National Neuroscience Institute, Singapore

 

 

10:25 – 10:55  BREAK                       

 

 

10:55 – 12:00 Session 3b. Precision Medicine and Stem Cell Models II

                        Chair: Christine CHEUNG, LKCM, Singapore

 

10:55 – 11:20  Integrating multi-omics data to improve understanding of T2D pathogenesis

Xueling SIM, National University of Singapore

 

11:20 – 11:35  Selected Abstract

                        Modelling genetic polycystic kidney disease using human pluripotent stem cell-derived kidney organoids

                        Meng LIU, Lee Kong Chian School of Medicine, Singapore

 

11:35 – 12:00  Singapore National Precision Medicine Program: Intersections with stem cell technologies

Patrick TAN, PRECISE, Singapore

 

 

12:00 – 13:00  BREAK                           

 

 

13:00 – 13:35  SCSS-Dr Susan Lim Award for Outstanding Young Investigator Presentation

                        Chair: Ray DUNN, Lee Kong Chian School of Medicine, Singapore

 

Retinal Cell Therapy: the path to vision regeneration                

Xinyi SU, Institute of Molecular and Cell Biology, Singapore

                       

13:35 – 16:10 Session 4. Stem Cell Therapy

Chair: Jonathan LOH, IMCB, Singapore

 

13:35 – 13:50  Selected Abstract

                        Understanding the molecular signature of mesenchymal stem cell quality

                        Padmapriya SATHIYANATHAN, Genome Institute of Singapore

 

13:50 – 14:10  Industry Talk

Characterization of stem cells for cellular therapies

Anis LARBI, Beckman Coulter Life Sciences, France

 

14:10 – 14:35  A learning journey of TCR-T therapy development

Qi-Jing LI, IMCB, Singapore

 

 

14:35 – 15:05  BREAK                       

 

 

15:05 – 15:30  Latest advances in ischemic and inflammatory disorders from Cytopeutics - focus on stroke and aGVHD

Sze Piaw CHIN, Cytopeutics Sdn. Bhd, Malaysia

 

15:30 – 15:45  Selected Abstract

                        Secretome derived from hypoxia preconditioned mesenchymal stem cells promote cartilage regeneration and mitigate joint inflammation via extracellular vesicles

                        Yanmeng YANG, National University of Singapore

 

15:45 – 16:10  From the skin to the joints: clinical translation, commercialisation and the future for cell-based regenerative therapies in orthopaedic surgery: where are we headed?

Francis WONG, Sengkang General Hospital, Singapore

           

 

16:10 – 18:15  POSTER SESSION with Wine & Cheese

                       

END OF DAY 2


Day 3, 9 December 2022

9: 00 – 12:00   Session 5. Emerging technologies in cell manufacturing

                        Chair: Yie Hou LEE, SMART, Singapore

 

9: 00 – 9:25     Label-free biophysical Critical Quality Attributes (CQAs) for cell therapy products

Jongyoon HAN, MIT/SMART, USA

 

9:25 – 9:50      Self-Sustaining Cell-Based Meat Paradigm: Making the muscle cell the serum source

Alfredo FRANCO-OBREGON, National University of Singapore

                       

9:50 – 10:15    Label-free selection of mesenchymal stem cell subpopulations with more efficacious cartilage regenerative potential

Zheng YANG, National University Health System, Singapore

 

10:15 – 10:45  BREAK                       

 

10:45 – 11:10  Mechanical control of mammalian ovarian folliculogenesis

Chii Jou (Joe) CHAN, Mechanobiology Institute, Singapore

 

11:10 – 11:35  Development of mechanotechnologies for high content imaging of scaffolded organoids

Virgile VIASNOFF, Mechanobiology Institute, Singapore

 

11:35 – 12:00 Stem cell differentiation via self-induced physical confinement

Andrew HOLLE, National University of Singapore

 

12:00 – 13:00  LUNCH BREAK                      

 

13:00 – 14:00 Session 6. STEMCELL Technologies hosted session - Organoids as tools for disease modelling

                        Chair: Riya SHARMA, STEMCELL Technologies, Canada

 

13:00 – 13:20 Efficient generation of functionally relevant hPSC-derived hepatocytes and liver organoids for hepatotoxicity and liver biology modeling

Riya SHARMA, STEMCELL Technologies, Canada

 

13:20 – 13:40  Implementing personalised medicine for cystic fibrosis patients: Personalised stem cell derived organoids to select optimal treatment for each patient

Shafagh WATERS, University of South Wales, Australia

 

13:40 – 14:00 DIVERSITY: A national organoid biobank for translational research

Nimmi BABY, Singapore Translational Cancer Consortium (STCC)

 

14:00 – 16:50 Session 7. Organoid models for human diseases

                       

This session is supported by the

LEE KONG CHIAN SCHOOL OF MEDICINE (LKCM), SINGAPORE

Chair: Yun XIA, Lee Kong Chian School of Medicine, Singapore

 

14:00 – 14:25  Modelling neural disorders using human pluripotent stem cells

                        Shawn JE, Duke-NUS Medical School, Singapore

                       

14:25 – 14:50  Human pluripotent stem cell-derived pancreatic islet cells for human diabetes modelling and target discovery

Natasha NG, Institute of Molecular and Cell Biology, Singapore

 

14:50 – 15:20  BREAK                       

 

15:20 – 15:45  Modular hydrogels for organoid-based disease modelling

Eileen GENTLEMAN, King’s College London, UK

 

15:45 – 16:10  Strategies to improve cardiovascular disease modelling in vitro

Boon Seng SOH, Institute of Molecular and Cell Biology, Singapore

 

16:10 – 16:25  Selected Abstract

                        Retinal organoid: a model to study embryonic retinal development

                        Ying CHEN, National University of Singapore

                                                                                                                                      

16:25 – 16:50  Kidney organoids for disease models and therapeutic development

Ryuji MORIZANE, Harvard Medical School, USA

 

16:50 – 17:25  Keynote lecture

Chair: Jonathan LOH, Institute of Molecular and Cell Biology, Singapore

 

De-aging the aging brain

Lee RUBIN, Harvard Stem Cell Institute, USA

 

17:25 – 17:40  AWARD PRESENTATION

                        CLOSING REMARKS

                        Chair: Li ZENG, National Neuroscience Institute, Singapore

 

END OF DAY 3 - FAREWELL


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