Programme (7-9 December)
(updated on 4 Dec 22)
(updated on 4 Dec 22)
Day 1, 7 December 2022
9:00 – 9:10 Welcome and opening
Ray DUNN, President
SCSS & Jonathan LOH, Chair of Organizing Committee
9:10
-9:45 Keynote lecture
Chair: Jonathan
LOH, Institute of Molecular and Cell Biology, Singapore
The Piwi-piRNA pathway: a New
World of gene regulation
Haifan LIN, Yale
School of Medicine, US
9:45 - 11:10 Session 1a. Precision Medicine and Stem
Cell Models I
Chair: Christine CHEUNG, LKCM, Singapore
9:45 - 10:10 Genome-scale CRISPR screening for LDLR-independent
pathways regulating LDL uptake
Haojie YU, National
University of Singapore
10:10 – 10:25 Selected Abstract
Characterization of LVV-transduced, in
vitro-expanded anti-TIM3 CAR T cells
Wei-Xiang
SIN, Singapore-MIT Alliance for Research and Technology (SMART), Singapore
10:25 – 10:45 Industry Talk
Leveraging genome
editing of iPSCs to create disease models
Yu ZOU, Thermo
Fisher Scientific, Singapore
10:45 – 11:10 Implications of cancer cell state plasticity
for therapeutic intervention
Wai Leong TAM, Genome
Institute of Singapore
11:10-
11:40 BREAK
11:40
– 12:45 Session
1b. Stem Cells, Ageing and Rejuvenation I
Chair: Li ZENG, National Neuroscience Institute, Singapore
11:40
– 12:05 Combining stem cell rejuvenation and senescence targeting to
synergistically extend lifespan
Nicholas Stanislaw
TOLWINSKI, Yale-NUS, Singapore
12:05
– 12:20 Selected
Abstract
Telomerase reverse transcriptase (TERT)
loss-of-function results in motor neuron and astrocyte ageing
Jasmine HARLEY,
Institute of Molecular and Cell Biology, Singapore
12:20
– 12:45 Asian
Immune Diversity Atlas (AIDA): Single cell analysis of human diversity
Kian Hong KOCK, Genome
Institute of Singapore
13:45 – 16:55 Session 2. Young Investigators’ Forum
Chair:
Natasha NG,
Institute of Molecular and Cell Biology, Singapore
13:45 – 14:10 Keynote lecture
Human
pluripotent stem cells, organoids and disease modelling
Shuibing CHEN, Cornell
University, USA
14:10 – 14:25 Selected Abstract
A stem cell-based toolkit to study deadly
biosafety level 4 viruses
Lay Teng ANG,
Stanford Institute for Stem Cell Biology & Regenerative Medicine, USA
14:25 – 14:40 Industry talk
Droplet
Digital PCR provides high sensitivity in the detection of pluripotent stem
cells
Kee Wah LEE, Bio-Rad
Laboratories (Singapore) Pte Ltd
14:40 – 15:05 Integrative analysis of single-cell
transcriptomics with multiplexed RNA imaging for mapping autism pathophysiology
Jinyue LIU, Genome
Institute of Singapore
15:05–
15:35 BREAK
15:35 – 16:25 Panel discussion – “Stories about career
transitions and the path to leadership in science”
Panellists:
Shi Yan NG, Principal Investigator, Institute of Molecular and Cell Biology, Singapore
Lisa OOI, Vice President (Strategy), Hummingbird Bioscience, Singapore
Fong Ming KOH, LYFE Capital, Singapore
Ying Xim TAN, Medisix
Therapeutics, Singapore
16:25 – 16:50 iPSC-driven inflection point in the cell therapy industry
Koji TANABE, I Peace, Japan
Chair: Jonathan Loh, Institute of Molecular and Cell Biology, Singapore
16:50
– 18:30 YOUNG INVESTIGATORS’ FORUM
NETWORKING & COCKTAIL RECEPTION
With a SPEED DATING
segment!
END OF DAY 1
Day 2, 8 December 2022
9:00 – 10:25 Session 3a. Stem Cells, Ageing and Rejuvenation
II
Chair: Li ZENG, National Neuroscience Institute, Singapore
9:00 – 9:25 Interventional strategies to enhance longevity
Brian KENNEDY, National
University of Singapore
9:25 – 9:45 Industry Talk
Enhancing survival: Novel methods for stem cell
colony selection and retrieval
Darius Cameron WILSON, Sartorius Corporation
9:45 – 10:00 Selected Abstract
Cord lining induced pluripotent stem
cell-derived retinal pigment epithelium (CLiPS-RPE):
A novel source for cell therapy for age-related macular degeneration (AMD)
Mayuri BHARGAVA,
Institute of Molecular and Cell Biology, Singapore
10:00 – 10:25 Communication between gut microbiota and organ
function regulates Biological Ageing
Sven PETTERSON,
National Neuroscience Institute, Singapore
10:25
– 10:55 BREAK
10:55 – 12:00
Session 3b. Precision Medicine and Stem
Cell Models II
Chair: Christine CHEUNG, LKCM, Singapore
10:55 – 11:20 Integrating
multi-omics data to improve understanding of T2D pathogenesis
Xueling
SIM, National University of Singapore
11:20 – 11:35 Selected Abstract
Modelling genetic polycystic kidney disease
using human pluripotent stem cell-derived kidney organoids
Meng LIU, Lee
Kong Chian School of Medicine, Singapore
11:35 – 12:00 Singapore
National Precision Medicine Program: Intersections with stem cell technologies
Patrick
TAN, PRECISE, Singapore
12:00
– 13:00 BREAK
13:00 – 13:35 SCSS-Dr Susan Lim Award for Outstanding Young
Investigator Presentation
Chair: Ray
DUNN, Lee Kong Chian School of Medicine, Singapore
Retinal Cell Therapy: the path to
vision regeneration
Xinyi SU, Institute of Molecular and Cell Biology, Singapore
13:35 – 16:10 Session 4. Stem Cell Therapy
Chair:
Jonathan LOH,
IMCB, Singapore
13:35 – 13:50 Selected Abstract
Understanding the molecular signature of
mesenchymal stem cell quality
Padmapriya
SATHIYANATHAN, Genome Institute of Singapore
13:50 – 14:10 Industry Talk
Characterization of stem cells for cellular
therapies
Anis LARBI, Beckman
Coulter Life Sciences, France
14:10 – 14:35 A learning journey of TCR-T therapy
development
Qi-Jing LI, IMCB,
Singapore
14:35
– 15:05 BREAK
15:05 – 15:30 Latest advances
in ischemic and inflammatory disorders from Cytopeutics - focus on stroke and aGVHD
Sze Piaw CHIN, Cytopeutics
Sdn. Bhd, Malaysia
15:30 – 15:45 Selected Abstract
Secretome derived from hypoxia preconditioned
mesenchymal stem cells promote cartilage regeneration and mitigate joint
inflammation via extracellular vesicles
Yanmeng YANG,
National University of Singapore
15:45 – 16:10 From the skin to the joints: clinical
translation, commercialisation and the future for
cell-based regenerative therapies in orthopaedic
surgery: where are we headed?
Francis WONG, Sengkang General Hospital, Singapore
16:10
– 18:15 POSTER SESSION with Wine &
Cheese
END OF DAY 2
Day 3, 9 December 2022
9:
00 – 12:00 Session
5. Emerging technologies in cell manufacturing
Chair: Yie Hou LEE, SMART, Singapore
9:
00 – 9:25 Label-free biophysical Critical Quality Attributes (CQAs) for
cell therapy products
Jongyoon
HAN, MIT/SMART, USA
9:25
– 9:50 Self-Sustaining
Cell-Based Meat Paradigm: Making the muscle cell the serum source
Alfredo FRANCO-OBREGON,
National University of Singapore
9:50
– 10:15 Label-free
selection of mesenchymal stem cell subpopulations with more efficacious
cartilage regenerative potential
Zheng YANG,
National University Health System, Singapore
10:15
– 10:45 BREAK
10:45 –
11:10 Mechanical control of mammalian ovarian folliculogenesis
Chii Jou (Joe) CHAN, Mechanobiology Institute, Singapore
11:10 – 11:35 Development
of mechanotechnologies for high content imaging of
scaffolded organoids
Virgile
VIASNOFF, Mechanobiology Institute, Singapore
11:35 – 12:00
Stem cell differentiation via self-induced physical confinement
Andrew
HOLLE, National University of Singapore
12:00
– 13:00 LUNCH BREAK
13:00 – 14:00 Session 6. STEMCELL Technologies hosted session
- Organoids as tools for disease modelling
Chair: Riya SHARMA, STEMCELL
Technologies, Canada
13:00 – 13:20 Efficient generation of
functionally relevant hPSC-derived hepatocytes and
liver organoids for hepatotoxicity and liver biology modeling
Riya SHARMA, STEMCELL Technologies,
Canada
13:20 – 13:40 Implementing personalised
medicine for cystic fibrosis patients: Personalised stem cell derived organoids
to select optimal treatment for each patient
Shafagh WATERS, University
of South Wales, Australia
13:40 – 14:00 DIVERSITY:
A national organoid biobank for translational research
Nimmi BABY, Singapore
Translational Cancer Consortium (STCC)
14:00 – 16:50 Session 7. Organoid models for human diseases
This
session is supported by the
LEE
KONG CHIAN SCHOOL OF MEDICINE (LKCM), SINGAPORE
Chair: Yun XIA, Lee Kong Chian School of Medicine, Singapore
14:00
– 14:25 Modelling neural disorders using human
pluripotent stem cells
Shawn JE, Duke-NUS
Medical School, Singapore
14:25
– 14:50 Human pluripotent stem cell-derived
pancreatic islet cells for human diabetes modelling and target discovery
Natasha NG,
Institute of Molecular and Cell Biology, Singapore
14:50
– 15:20 BREAK
15:20
– 15:45 Modular
hydrogels for organoid-based disease modelling
Eileen
GENTLEMAN, King’s College London, UK
15:45 – 16:10 Strategies to improve
cardiovascular disease modelling in vitro
Boon Seng SOH, Institute
of Molecular and Cell Biology, Singapore
16:10 – 16:25 Selected
Abstract
Retinal organoid: a model to study embryonic
retinal development
Ying CHEN, National
University of Singapore
16:25 – 16:50 Kidney
organoids for disease models and therapeutic development
Ryuji
MORIZANE, Harvard Medical School, USA
16:50
– 17:25 Keynote lecture
Chair: Jonathan
LOH, Institute of Molecular and Cell Biology, Singapore
De-aging the
aging brain
Lee RUBIN, Harvard
Stem Cell Institute, USA
17:25
– 17:40 AWARD PRESENTATION
CLOSING
REMARKS
Chair: Li ZENG, National
Neuroscience Institute, Singapore
END OF DAY 3
- FAREWELL
Organized by:
