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Programme


Day 1 -Day3, 8-10 December 2021


PROGRAMME

 

Day 1, 8 December 2021

 

 

Welcome & Opening of Symposium

9:15 – 9:30            Welcome Address by Ray DUNN, President Stem Cell Society Singapore

 

 

Session 1. KSSCR session: partnering for stem cell research

                Chairs: Jihwan SONG, CHA University, Korea & Jongpil KIM, Dongguk University, Korea

9:30 – 10:05         KEYNOTE LECTURE

Stem cell therapy for Huntington's disease

Jihwan SONG, Cha University, Korea

 

10:05 – 10:30       Application of stem cell-derived extracellular vesicles for IC/BPS treatment

Ssang-Goo CHO, Konkuk University, Korea

 

10:30 – 10:55       Regulation of protein stability of stemness factors

Jaeho KIM, Pusan National University, Korea

 

10:55 – 11:00       SHORT BREAK

 

11:00 – 11:25       Recent advances in cell reprogramming, 3D organoids and gene editing technology as the novel  therapeutics for neurological diseases

Jongpil KIM, Dongguk University, Korea

 

11:25 – 11:50       Reprogramming with pluripotency factors for Parkinson’s disease

                                Janghwan KIM, KRIBB, Korea

 

11:50 – 12:00       Selected Abstract

                                Integrative and quantitative analysis of transcription factors in cell fate determination during early mouse brain development

                                Yue ZHUO, German Cancer Research Center (DKFZ)

 

12:00 – 13:00       LUNCH BREAK

 

 


 

Session 2. Cell therapies in the Asia Pacific, 2021 review & updates

                                Chair: Steve OH, Bioprocessing Technology Institute, Singapore

13:00 – 13:20       MiRXES – Delivering from research to commercialization

Lihan ZHOU, MiRXES, Singapore

 

13:20 – 13:40       Development and manufacture of lentiviral vectors for clinical gene therapy

Lucas CHAN, Cellvec, Singapore

 

13:40 – 14:00       Label-free technology to predict stem cell donor and media quality

Pascale Yan CHARBONNEL, Ovizio Imaging Systems NV/SA, Belgium

Will HEATON, DiscGenics, USA

 

14:00 – 14:20       SB623: Challenges in Supply and Manufacturing

Julia CHER & Shin HONG, SanBio, USA

 

14:20 – 14:25       SHORT BREAK

 

14:25 – 14:45       Bioengineered human heart chambers for disease modelling and drug discovery & development

Ronald LI, Novoheart, Hongkong

 

14:45 – 14:55       Selected Abstract

                                Identification and validation of subtype-specific surface markers for human pluripotent stem cells-derived cardiomyocytes

                                Lee Chuen LIEW, Institute of Molecular and Cell Biology, Singapore

 

14:55 – 15:15       From chemotherapy to immunotherapy of classical Hodgkin Lymphoma

Ivan David HORAK, Tessa Therapeutics, Singapore

 

15:15 – 15:35       Cell therapy manufacturing: Overview and general considerations

                                David LOONG, Merck Life Sciences, Singapore

 

15:35 – 15:55       Utilizing 3D suspension culture for the efficient generation of large numbers of pluripotent stem cells

                                Michael AKENHEAD, Thermofisher Scientific, USA

 

 

15:55 – 16:30       BREAK

 

 

Session 3. Beckman Coulter Session

Chair: Michael KAPINSKY, Beckman Coulter Life Sciences, Germany

 

16:30 – 17:00       Sex-related immunophenotype differences of stromal vascular fraction revealed by polychromatic flow cytometry

                                Denis POLANCEC, Srebrnjak Children's Hospital, Croatia

 

17:00 – 17:30       Dry reagent technology for standardized phenotyping of human adult stem cells

                                Michael KAPINSKY, Beckman Coulter Life Sciences. Germany

 

17:30 – 17:45       BREAK

 

 

17:45 – 18:45       Rapid-fire presentations Session A

Moderator: Ray DUNN, LKCM, Singapore

 

 

18:45                      END OF DAY 1

 


 

Day 2, 9 December 2021

 

 

Session 4. Overcoming host immunological barriers for cell therapies

 

Chair: Jonathan LOH, Institute of Molecular and Cell Biology, Singapore

 

9:30– 9:50             Engineering allogeneic T-cell therapies resistant to host immune rejection

Maksim MAMONKIN, Baylor College of Medicine, USA

 

9:50 – 10:10         Genome editing iPS cells for escaping allogeneic immune rejection

Akitsu HOTTA, Kyoto University, Japan

 

10:10 – 10:30       Ex vivo stromal cell immunotherapy

Biju PAREKKADAN, Rutgers University, USA

 

10:30 – 10:40       Selected Abstract

                                Retinal pigment epithelial cells derived from a novel source of induced pluripotent stem cells evade immune detection in humanized mice

                                Bhav PARIKH, Institute of Molecular and Cell Biology, Singapore

 

10:40– 10:45        SHORT BREAK

 

10:45 – 11:05       Overcoming the host immune responses for cell therapies

Sonja SCHREPFER, University of California San Francisco, USA

 

11:05 – 11:25       Immune cell generation from human pluripotent stem cells in feeder- and serum-free cultures

                                Tim LeFevre, STEMCELL Technologies, Canada

 

11:25 – 11:45       Harnessing the anti-tumor functions of γδT cells in cancer immunotherapy

Haiyan LIU, National University of Singapore

 

 

11:45 – 13:00       LUNCH BREAK

 

 


 

Session 5. Stem cells for sustainability: potential of cellular agriculture

Chair: Shigeki SUGII, Institute of Bioengineering and Bioimaging, Singapore

 

13:00 – 13:25       SFA regulation for alternative proteins

Stan CHAN, Singapore Food Agency, Singapore

 

13:25– 13:50        The Good Food Institute and scientific advances of cultivated meat

Dean POWELL, Good Food Institute (GFI) Asia-Pacific, Singapore

 

13:50 – 14:10       Tendon-gel assisted 3D-bioprinting for construction of structured wagyu meat-like tissues

Michiya MATSUSAKI, Osaka University, Japan

 

14:10 – 14:15       SHORT BREAK

 

14:15 – 14:35       Shiok Meats: Cell-based crustaceans for sustainable future of food

Ka Yi LING, Shiok Meats, Singapore

 

14:35 – 14:55       CentRe of Innovation for sustainable banking and production of cultivated meats (CRISP meats): Establishing novel technologies for cost effective production of cell-based meat

Andy TAN, BTI and CRISP Meats programme - A*STAR, Singapore

 

14:55 – 15:15       Stem cells and scaffolds enable the generation of bovine muscle and fat tissues for cell-based meat

Shulamit LEVENBERG, Technion - Israel Institute of Technology and Aleph Farms, Israel

 

15:15 – 15:25       Selected Abstract

                                Fish-derived cultivated adipocytes for cellular agriculture

Lamony CHEW, Institute of Bioengineering and Bioimaging, Singapore

 

15:25 – 16:00       BREAK

 

Session 6 Teaser. Modeling human development: the journey from pluripotency to cell fate specification

 

                                Chair: Ray DUNN, LKCM, Singapore

 

16:00 – 16:20       Understanding human liver development using stem cells and organoids

Ludovic Vallier, University of Cambridge, UK

 

Rapid-fire presentations

 

16:20 – 17:20       Rapid-fire presentations Session B

Moderator: Ray DUNN, LKCM, Singapore

 

17:20                      END OF DAY 2

 

 


 

Day 3, 10 December 2021

 

 

9:00 – 9:35            KEYNOTE LECTURE

                               

                                This talk is supported by the

                                INSTITUTE OF MOLECULAR AND CELL BIOLOGY (IMCB), SINGAPORE

 

Chair: Jonathan LOH, IMCB, Singapore

 

Stem cell science and the genesis of new therapeutic strategies for patients

Derrick ROSSI, Harvard University, USA

 

Session 6. Modeling human development: the journey from pluripotency to cell fate specification

                                This session is supported by the

                                LEE KONG CHIAN SCHOOL OF MEDICINE (LKCM), SINGAPORE

 

                Chairs:   Ray DUNN, LKCM, Singapore & Yun XIA, LKCM, Singapore

9:35 – 9:55            Generation of human blastocyst-like structure from naive pluripotent stem cells

                                Jun WU, University of Texas Southwestern, Dallas. USA

 

9:55 – 10:15         Kidney progenitors in kidney development, disease, and regeneration

Zhongwei LI, University of Southern California, Los Angeles, USA

 

10:15 – 10:35       Acquisition of alveolar signature in the developing human lung: lessons from organoids

Kyungtae LIM, University of Cambridge, UK

 

10:35 – 10:40       SHORT BREAK

 

10:40 – 11:00       Hair shaft miniaturization causes stem cell depletion through mechano-sensory signals mediated by a Piezo1-calcium-TNFα axis

Ting CHEN, National Institute of Biological Sciences, Beijing, China

 

11:00 – 11:10       Selected Abstract

                                LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells

María Ángeles MARQUÉS-TORREJÓN, University of Edinburgh, UK

 

11:10 – 11:30       Investigating kidney development to guide cellular engineering

Alex COMBES, Monash University, Melbourne, Australia

 

11:30 – 11:40       Resolving biological complexities of organoid models with single cell and spatial solutions

                                Ivonne PETERMANN, 10x Genomics, Australia

 

11:40 – 11:50       Advancements in Next-Generation Sequencing for stem cell research

                                Justin LEE, NovogeneAIT Genomics, Singapore

 

11:50 – 13:15       LUNCH BREAK

 

 


 

Session 7. Cell-based immunotherapy product development

                               

                                Chairs: Sudipto BARI, ACTRIS, Singapore & Francesca LIM, Singapore General Hospital

 

13:15 – 13:35       Engineered NK cells: shaping the future of cancer immunotherapy

                                May DAHER, MD Anderson Cancer Center, USA

 

13:35 – 13:55       Discovery of T cell receptors for application in immune-based cancer therapy

Katja FINK, ImmunoScape Pte. Ltd., Singapore

 

13:55 – 14:15       Cell, tissue and gene therapy products regulations

                                Lee Lee ONG, Health Sciences Authority, Singapore

 

14:15 – 14:20       SHORT BREAK

 

14:20 – 14:40       Industrializing Cell & Gene Therapy

Janet MACPHERSON, Cytiva, Australia

 

14:40– 14:50        Selected Abstract

                                Defined alternatives to basal membrane extract for spinal organoid generation

Wai Hon CHOOI, Institute of Molecular and Cell Biology, Singapore

 

14:50– 15:05        Introduction to SingHealth Duke-NUS Cell Therapy Centre

                                William HWANG, SingHealth Duke-NUS Cell Therapy Centre (SDCT), Singapore

 

15:05 – 15:25       The utility of FISH in Ph-like ALL; prognostic impact on outcome in adult ALL

Patricia GREIPP, MAYO CLINIC, USA

 

15:25 – 15:45       How do therapeutic companies reduce development time and cost?

                                Jason DOWD, CCRM, Canada

 

 

15:45 – 16:00       BREAK

 

 

Session 6 Continued. Modeling human development: the journey from pluripotency to cell fate specification

 

                                Chair:     Ray DUNN, LKCM, Singapore                         

 

16:00 – 16:20       Building advanced human neuromuscular organoid models to study development and disease

                                Mina GOUTI, Max-Delbrück Center for Molecular Medicine (MDC), Berlin, Germany

                               

Session 8. Susan Lim Award Lecture

 

16:20 – 16:50       Using stem cells to understand human neurological disorders and ways to treat them

Shi Yan NG, Institute of Molecular and Cell Biology, Singapore

 

16:50                      END OF DAY 3 & FAREWELL

 

 


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