Programme
Day 1 -Day3, 8-10 December 2021
PROGRAMME
Day 1, 8 December 2021
Welcome & Opening of Symposium
9:15 – 9:30 Welcome Address by Ray DUNN,
President Stem Cell Society Singapore
Session 1. KSSCR session:
partnering for stem cell research
Chairs: Jihwan SONG, CHA University, Korea & Jongpil KIM, Dongguk University,
Korea
9:30
– 10:05 KEYNOTE LECTURE
Stem cell
therapy for Huntington's disease
Jihwan SONG, Cha
University, Korea
10:05
– 10:30 Application of stem
cell-derived extracellular vesicles for IC/BPS treatment
Ssang-Goo CHO, Konkuk University, Korea
10:30
– 10:55 Regulation of protein
stability of stemness factors
Jaeho KIM, Pusan
National University, Korea
10:55
– 11:00 SHORT BREAK
11:00
– 11:25 Recent advances in cell
reprogramming, 3D organoids and gene editing technology as the novel therapeutics
for neurological diseases
Jongpil
KIM, Dongguk University, Korea
11:25
– 11:50 Reprogramming with
pluripotency factors for Parkinson’s disease
Janghwan KIM, KRIBB, Korea
11:50
– 12:00 Selected Abstract
Integrative and
quantitative analysis of transcription factors in cell fate determination
during early mouse brain development
Yue ZHUO, German
Cancer Research Center (DKFZ)
12:00 – 13:00 LUNCH BREAK
Session 2. Cell therapies in
the Asia Pacific, 2021 review & updates
Chair: Steve OH, Bioprocessing Technology
Institute, Singapore
13:00
– 13:20 MiRXES – Delivering from research to commercialization
Lihan ZHOU, MiRXES, Singapore
13:20
– 13:40 Development and manufacture
of lentiviral vectors for clinical gene therapy
Lucas CHAN, Cellvec, Singapore
13:40 – 14:00 Label-free
technology to predict stem cell donor and media quality
Pascale Yan CHARBONNEL, Ovizio Imaging Systems
NV/SA, Belgium
Will HEATON, DiscGenics, USA
14:00
– 14:20 SB623: Challenges in Supply and Manufacturing
Julia CHER
& Shin HONG, SanBio, USA
14:20
– 14:25 SHORT BREAK
14:25
– 14:45 Bioengineered human heart chambers for disease modelling and drug
discovery & development
Ronald LI, Novoheart, Hongkong
14:45
– 14:55 Selected Abstract
Identification
and validation of subtype-specific surface markers for human pluripotent stem
cells-derived cardiomyocytes
Lee Chuen LIEW, Institute
of Molecular and Cell Biology, Singapore
14:55
– 15:15 From chemotherapy to immunotherapy of classical Hodgkin Lymphoma
Ivan David HORAK,
Tessa Therapeutics, Singapore
15:15
– 15:35 Cell therapy
manufacturing: Overview and general considerations
David LOONG, Merck
Life Sciences, Singapore
15:35
– 15:55 Utilizing 3D suspension
culture for the efficient generation of large numbers of pluripotent stem cells
Michael AKENHEAD,
Thermofisher
Scientific, USA
15:55 – 16:30 BREAK
Session 3. Beckman Coulter
Session
Chair:
Michael KAPINSKY, Beckman Coulter Life Sciences, Germany
16:30
– 17:00 Sex-related immunophenotype differences of stromal vascular fraction
revealed by polychromatic flow cytometry
Denis POLANCEC, Srebrnjak Children's Hospital, Croatia
17:00
– 17:30 Dry reagent technology for standardized phenotyping of human adult stem
cells
Michael KAPINSKY,
Beckman Coulter Life Sciences. Germany
17:30
– 17:45 BREAK
17:45
– 18:45 Rapid-fire presentations
Session A
Moderator: Ray
DUNN, LKCM, Singapore
18:45 END OF DAY 1
Day 2, 9 December 2021
Session 4. Overcoming host immunological barriers
for cell therapies
Chair:
Jonathan LOH, Institute of Molecular and Cell Biology, Singapore
9:30–
9:50 Engineering
allogeneic T-cell therapies resistant to host immune rejection
Maksim MAMONKIN, Baylor College of Medicine, USA
9:50
– 10:10 Genome editing iPS
cells for escaping allogeneic immune rejection
Akitsu
HOTTA, Kyoto University, Japan
10:10
– 10:30 Ex vivo stromal cell immunotherapy
Biju
PAREKKADAN, Rutgers University, USA
10:30
– 10:40 Selected Abstract
Retinal pigment epithelial cells
derived from a novel source of induced pluripotent stem cells evade immune
detection in humanized mice
Bhav PARIKH, Institute of Molecular and Cell Biology,
Singapore
10:40–
10:45 SHORT BREAK
10:45
– 11:05 Overcoming the host immune responses for
cell therapies
Sonja SCHREPFER, University of California San Francisco, USA
11:05
– 11:25 Immune cell generation from human pluripotent stem cells in feeder- and
serum-free cultures
Tim LeFevre, STEMCELL
Technologies, Canada
11:25
– 11:45 Harnessing the anti-tumor functions of γδT
cells in cancer immunotherapy
Haiyan LIU, National
University of Singapore
11:45 – 13:00 LUNCH BREAK
Session 5. Stem cells for sustainability:
potential of cellular agriculture
Chair:
Shigeki SUGII, Institute of Bioengineering and Bioimaging, Singapore
13:00
– 13:25 SFA regulation for alternative proteins
Stan CHAN, Singapore
Food Agency, Singapore
13:25–
13:50 The Good Food Institute and scientific advances of cultivated meat
Dean POWELL, Good
Food Institute (GFI) Asia-Pacific, Singapore
13:50
– 14:10 Tendon-gel assisted 3D-bioprinting for construction of structured wagyu
meat-like tissues
Michiya MATSUSAKI,
Osaka University, Japan
14:10
– 14:15 SHORT BREAK
14:15 – 14:35 Shiok
Meats: Cell-based crustaceans for sustainable future of food
Ka Yi LING, Shiok Meats, Singapore
14:35
– 14:55 CentRe of Innovation for sustainable banking and production of cultivated
meats (CRISP meats): Establishing novel technologies for cost effective
production of cell-based meat
Andy TAN, BTI
and CRISP Meats programme - A*STAR, Singapore
14:55
– 15:15 Stem
cells and scaffolds enable the generation of bovine muscle and fat tissues for
cell-based meat
Shulamit LEVENBERG, Technion
- Israel Institute of Technology and Aleph Farms, Israel
15:15
– 15:25 Selected Abstract
Fish-derived cultivated adipocytes
for cellular agriculture
Lamony CHEW, Institute
of Bioengineering and Bioimaging, Singapore
15:25 – 16:00 BREAK
Session
6 Teaser. Modeling human
development: the journey from pluripotency to cell fate specification
Chair: Ray DUNN, LKCM, Singapore
16:00
– 16:20 Understanding human liver
development using stem cells and organoids
Ludovic
Vallier, University of Cambridge, UK
Rapid-fire
presentations
16:20
– 17:20 Rapid-fire presentations
Session B
Moderator: Ray
DUNN, LKCM, Singapore
17:20 END OF DAY 2
Day 3, 10 December 2021
9:00 – 9:35 KEYNOTE
LECTURE
This
talk is supported by the
INSTITUTE
OF MOLECULAR AND CELL BIOLOGY (IMCB), SINGAPORE
Chair: Jonathan LOH, IMCB, Singapore
Stem
cell science and the genesis of new therapeutic strategies for patients
Derrick ROSSI, Harvard University, USA
Session 6. Modeling human
development: the journey from pluripotency to cell fate specification
This
session is supported by the
LEE
KONG CHIAN SCHOOL OF MEDICINE (LKCM), SINGAPORE
Chairs: Ray DUNN, LKCM,
Singapore & Yun XIA, LKCM, Singapore
9:35
– 9:55 Generation of human
blastocyst-like structure from naive pluripotent stem cells
Jun
WU, University of Texas Southwestern, Dallas. USA
9:55
– 10:15 Kidney progenitors in
kidney development, disease, and regeneration
Zhongwei LI, University
of Southern California, Los Angeles, USA
10:15
– 10:35 Acquisition of alveolar
signature in the developing human lung: lessons from organoids
Kyungtae LIM,
University of Cambridge, UK
10:35
– 10:40 SHORT BREAK
10:40
– 11:00 Hair shaft
miniaturization causes stem cell depletion through mechano-sensory signals
mediated by a Piezo1-calcium-TNFα axis
Ting CHEN, National
Institute of Biological Sciences, Beijing, China
11:00
– 11:10 Selected Abstract
LRIG1 is a gatekeeper
to exit from quiescence in adult neural stem cells
María Ángeles MARQUÉS-TORREJÓN, University of Edinburgh, UK
11:10
– 11:30 Investigating kidney
development to guide cellular engineering
Alex COMBES, Monash
University, Melbourne, Australia
11:30
– 11:40 Resolving biological
complexities of organoid models with single cell and spatial solutions
Ivonne
PETERMANN, 10x Genomics, Australia
11:40 – 11:50 Advancements in Next-Generation
Sequencing for stem cell research
Justin LEE, NovogeneAIT Genomics, Singapore
11:50 – 13:15 LUNCH BREAK
Session 7. Cell-based immunotherapy product development
Chairs: Sudipto BARI, ACTRIS, Singapore & Francesca
LIM, Singapore General Hospital
13:15
– 13:35 Engineered NK cells: shaping the future of cancer
immunotherapy
May DAHER, MD
Anderson Cancer Center, USA
13:35 – 13:55 Discovery of T cell receptors for
application in immune-based cancer therapy
Katja FINK, ImmunoScape
Pte. Ltd., Singapore
13:55
– 14:15 Cell, tissue and gene therapy products
regulations
Lee
Lee ONG, Health Sciences Authority, Singapore
14:15
– 14:20 SHORT BREAK
14:20 – 14:40 Industrializing Cell & Gene
Therapy
Janet MACPHERSON, Cytiva,
Australia
14:40– 14:50 Selected Abstract
Defined
alternatives to basal membrane extract for spinal organoid generation
Wai Hon CHOOI, Institute
of Molecular and Cell Biology, Singapore
14:50– 15:05 Introduction to SingHealth Duke-NUS Cell Therapy Centre
William HWANG, SingHealth
Duke-NUS Cell Therapy Centre (SDCT), Singapore
15:05 – 15:25 The utility of FISH in Ph-like ALL;
prognostic impact on outcome in adult ALL
Patricia GREIPP, MAYO
CLINIC, USA
15:25
– 15:45 How do therapeutic
companies reduce development time and cost?
Jason DOWD, CCRM,
Canada
15:45 – 16:00 BREAK
Session 6 Continued. Modeling
human development: the journey from pluripotency to cell fate specification
Chair: Ray
DUNN, LKCM, Singapore
16:00
– 16:20 Building advanced human neuromuscular
organoid models to study development and disease
Mina
GOUTI, Max-Delbrück Center for Molecular Medicine (MDC), Berlin, Germany
Session 8. Susan Lim Award Lecture
16:20
– 16:50 Using stem cells to
understand human neurological disorders and ways to treat them
Shi Yan NG, Institute
of Molecular and Cell Biology, Singapore
16:50 END OF DAY 3 &
FAREWELL
Jointly Organized by:
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