Arnold KRIEGSTEIN UCSF, USA "Genomic insights into human brain development, disease and evolution"
ABSTRACT We have sequenced mRNA from single human progenitor cells and young neurons across developmental timepoints for unbiased classification of cell identity and for detection of activated signaling pathways. Our genomic data has informed a novel model of primate corticogenesis, identified mechanisms of arealization, suggested a relationship between oRG cells and brain tumors, and benchmarked in vitro organoid models of brain development and disease.
BIO Arnold Kriegstein received a BS from Yale University and MD and PhD from New York University. He completed Neurology Residency at the Brigham and Women’s, Children’s, and Beth Israel Hospitals, Boston, and is a board-certified clinical neurologist and member of the National Academy of Medicine. He has held academic appointments at Stanford, Yale, and Columbia before joining UCSF in 2004. Dr. Kriegstein’s research focuses on human brain development and disease.