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View  Andrews's webinar on-demand!

Date:   24 May 2022 (Tuesday)

Time:   11am - 12pm

Format: Zoom Webinar (registration is required)

Hosted by: Adrian Teo,
IMCB & Vice-treasurer SCSS

Speaker's information

Andrew ELEFANTY
The Royal Children's Hospital, Australia
"Modelling human haematopoietic development in vitro with pluripotent stem cells"

Picture
ABSTRACT
Human blood development occurs in several waves at different embryonic sites, regulated by time sensitive, complex signaling networks. To recapitulate haematopoiesis in vitro, we have differentiated human pluripotent stem cells (hPSCs) using protocols that can generate extra embryonic (yolk-sac like) or intra embryonic (AGM-like) progeny. Single cell RNA-sequencing of differentiated cultures enabled us to study the relationships between mesoderm derived endothelial progenitors, blood cells and stromal elements. Transcriptomic analysis revealed extensive heterogeneity of early haematopoietic and endothelial cells. Comparing the hPSC-derived blood and endothelium cells with datasets of early human blood development, we found a high degree of similarity between in vivo and in vitro generated venous and arterial endothelial cells as well as hematopoietic stem and progenitor cells. Some points of difference between the transcriptional profiles of hPSC-derived and human embryonic haematopoiesis were also identified, providing clues how to further improve differentiation protocols.

BIO
Andrew Elefanty's laboratory has focused on the differentiation of pluripotent stem cells for many years, working with mouse and then with human PSC since 2002. His main focus has been on the differentiation of PSC towards blood cell lineages. Together with his long term collaborators Elizabeth Ng and Ed Stanley, his goal is to generate cells for transplantation and to model blood diseases in vitro. 

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  • Home
  • Our Society
    • Office Bearers & Exco
    • Cell Therapy Focus Group
  • ISSCR-SCSS Symposium 2024
    • Poster Guide 2024
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    • AGM 2024
    • Past SCSS Events
      • Past SCSS Symposia
        • SCSS Symposium 2023
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          • Poster Guide 2023
          • Organizing Committee 2023
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          • Support Packages 2023
        • SCSS Symposium 2022
          • Programme
          • Organizing Committee
          • Poster Guide 2022
          • Exhibition Hall 2022
          • Registration
          • Supporters 2022
        • SCSS Symposium 2021
          • Organizing Committee
          • Speakers
          • Programme
          • Supporters
        • SCSS-JSRM 2020
          • Supporters 2020
          • Organizing Committee 2020
        • SCSS-ISCT 2019
          • Speakers
          • Registration
          • Support Us
            • Support Packages
            • Floor Plan
            • Terms & Conditions
            • Order Form
          • Programme
        • EMBO Workshop 2018
        • SCSS Symposium 2017
        • SCSS Symposium 2016
        • Symposia before 2016
  • Resources
    • Awards
      • SCSS Dr. Susan Lim Award
    • Fellowships
      • Overseas Travel Fellowship Programme
      • SCSS Symposium Fellowships
    • Information on Stem Cells
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  • Contact