TENTative Schedule (subject to changes)
Day 1, 8 December 2021
Welcome
Address & MOU Ceremony
9:15 – 9:30 Welcome Address (Hongyan WANG (Chair
of the Organizing Committee)
MOU Ceremony (Ray
DUNN, President SCSS & Yoshiki SAWA, President JSRM)
Session 1. Advancing
Cell Therapies in Japan and Beyond: Session with the Japanese Society for
Regenerative Medicine (JSRM)
Chair: Shigeki
Sugii, IBN, Singapore
9:30
– 10:05 KEYNOTE LECTURE
Frontier
regenerative medicine in cardiovascular area and Overview of JSRM
Yoshiki
SAWA, Osaka University, Japan
10:05
– 10:30 JSRM: an academic society as
an open innovation platform
Kyosuké MANO, The
Japanese Society for Regenerative Medicine, Japan
10:30
– 10:55 FZD5 regulates cellular
senescence in human mesenchymal stem/stromal cells
Yo
MABUCHI, Tokyo Medical and Dental University, Japan
10:55 – 11:20 Development of human resources of operators
in JSRM and current topics for cell manufacturing
Masahiro KINO-OKA, Osaka
University, Japan
11:20
– 11:45 iPSCs-based regenerative medicine
for spinal cord injury and drug development for ALS
Hideyuki OKANO, Keio
University, Japan
11:45
– 12:10 Establishment of next
generation peripheral blood vascular regeneration cell therapy
Rica TANAKA,
Juntendo University, Japan
12:10 –
13:00 BREAK – EXHIBITORS AND SPONSORS
SHOWCASE
Session
2. STEMCELL Technologies Session - Organoids
as Tools for Disease Modelling
Chair:
Ryan CONDER, STEMCELL Technologies, Canada
13:00
– 13:10 Corporate Video presentation
13:10
– 13:30 Recent developments and applications using organoids
Ryan CONDER, STEMCELL Technologies,
Canada
13:30 –
13:50 Human pluripotent stem cell-derived pancreatic beta cells for studying
diabetes disease mechanisms
Adrian TEO, Institute of Molecular
and Cell Biology, Singapore
13:50 –
14:10 The use of human induced pluripotent stem cell-derived cerebral
organoids to investigate the role of apolipoproteins e in Alzheimer's Disease
Damian HERNANDEZ, The
University of Melbourne, Australia
14:10
– 14:30 3D midbrain organoids: A 3rd dimension to investigate PD pathogenesis
Alfred SUN, Genome Institute of
Singapore
14:30 – 14:45 BREAK
Session
3. In-vitro models of Health and Disease
Chair:
Ray Dunn, Lee Kong Chian School of Medicine, Singapore
14:45– 15:10 ALS
motor neurons exhibit hallmark metabolic defects that are rescued by SIRT3
activation
Shi Yan NG, Institute of Molecular and Cell
Biology, Singapore
15:10 –
15:35 Molecular underpinning of
vascular endothelial dysfunction in polypoidal choroidal vasculopathy
Christine
CHEUNG, Lee Kong Chian School of Medicine, Singapore
15:35 –
16:00 Defining essential enhancers for pluripotent stem cells using a
features-oriented CRISPR-Cas9 screen
Jonathan
LOH, Institute of Molecular and Cell Biology, Singapore
16:00
– 16:15 BREAK
16:15
– 16:40 Chromatin wiring and re-wiring in the heart
Roger FOO, Genome
Institute of Singapore
16:40
– 17:05 Modeling of endothelial dysfunction using hiPSCs
reprogrammed from patients with
T2DM
Lei YE, National
Heart Centre, Singapore
17:05
– 17:20 Selected abstract
Stem cell differentiation into mature
pancreatic islets for diabetes cell therapy
Punn
AUGSORNWORAWAT and Jeffrey R MILLMAN, Washington
University in St. Louis, US
17:20 – 17:45 Patient-specific
Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a
gene dose-sensitive AD suppressor in human brain
Aoife
MURRAY, Queen Mary University of London, UK
17:45
– 18:00 BREAK
18:00
– 19:00 Session 4. Live Fire-talks
1
Moderator:
Ray DUNN, LKCM, Singapore
Presenters:
Natasha
NG, IMCB, Singapore
Avinanda
BANERJEE, inStem, India
Jun
Wei CHAN, IMCB, Singapore
Tong
Ming LIU, IMCB, Singapore
Durga
Shankar SHARMA, University of Hyderabad, India
Alan
LAM, Bioprocessing Technology Institute, Singapore
19:00 END OF DAY 1
Day 2, 9 December 2021
Session
5. Neural Stem Cells and Neurological Disorders
Chair: Hongyan WANG, Duke-NUS Medical School,
Singapore
Postnatal neural stem cells and prospects for
neuronal replacement
Arturo ALVAREZ-BUYLLA, University of California San Francisco, USA
9:35– 10:00 Differential metabolic
profiles confer resistance in glioblastoma therapies: stratification goals and
implementation
Carol TANG, National
Neuroscience Institute, Singapore
10:00
– 10:25 Channel dysfunction underlying
epilepsy of Angelman Syndrome
Qiang YUAN, Duke-NUS,
Singapore
10:25
– 10:40 Selected abstract
Msps governs acentrosomal microtubule assembly and
reactivation of quiescent neural stem cells
Qiannan Deng, Duke-NUS
Medical School, Singapore
10:40
– 10:55 BREAK
10:55
– 11:20 Neural stem cells and neurological disorders
Louise CHENG, Peter McCallum Cancer Centre, Australia
11:20
– 11:45 In-vitro modeling of dementia using 3d techniques
Li ZENG, National Neuroscience Institute, Singapore
11:45 – 12:10 Mechanisms
that regulate brain stem cell proliferation in the normal brain and brain
tumors
Derrick ONG,
National University of Singapore
12:10 –
13:00 BREAK – EXHIBITORS AND SPONSORS
SHOWCASE
Session 6. Deconstructing and
Reconstructing Organogenesis
Chair: Christine CHEUNG, Lee Kong Chian School
of Medicine, Singapore
13:00 – 13:25 Deciphering the aetiology of
pancreatic hypoplasia in Mitchell-Riley Syndrome
Ray DUNN, Lee Kong Chian School of Medicine,
Singapore
13:25 – 13:50 Surgical
transplantation of human RPE stem cell derived RPE (hRPESC-RPE)
monolayers into non-human primates with immunosuppression
Xinyi SU, Institute of Molecular and Cell
Biology, Singapore
13:50 – 14:15 Stem
cell derived liver organoids
Winston CHAN, Genome Institute of Singapore,
Singapore
14:15 – 14:30 Selected abstract
A 3D-printed
GelMA scaffold assembly for the co-culture of human
endothelial cells and beta cells
Alvin Soetedjo, Institute
of Molecular and Cell Biology, Singapore
14:30 – 14:45 BREAK
14:45 – 15:10 Biomimetic
materials in medicine and beyond
Javier GOMEZ FERNANDEZ, Singapore University
of Design & Technology
15:10 – 15:35 Using
human pluripotent stem cells to understand airway basal cell development
Kim Jee GOH, Lee Kong Chian School of Medicine, Singapore
15:35 – 16:00 Infection and immunity of SARS-CoV-2
infections: diagnostics & therapies for COVID-19
Lisa NG, Singapore Immunology Network
16:00 – 16:30 BREAK
16:30
– 17:30 Session 7. Live
Fire-talks 2
Moderator:
Christine CHEUNG, LKCM
Presenters:
Matias
AUTIO, Genome Institute of Singapore
Parvathi
CHANDRAN, Regrow Biosciences, India
Wei Xuan
TAN, IMCB, Singapore
Yisheng CUI, Osaka
University, Japan
Patrick
FOONG, Western Sydney University, Australia
Rubina
SHAKYA, Mahidol University, Thailand
Lillian LIM,
IMCB, Singapore
17:30 END OF DAY 2
Day 3, 10 December 2021
Session
8. Cell-based and Immuno Therapies
Chair: Simon
COOL, Institute of Molecular and Cell Biology, Singapore
9:30
– 9:55 Optimising blood stem cell
transplants through cellular engineering
William
HWANG, National Cancer Centre, Singapore
9:55
– 10:20 From SARS to COVID-19 in Singapore: The role of virus-specific T-cells
Antonio
BERTOLETTI, Duke-NUS, Singapore
10:20
– 10:45 MSC Regenerative Medicine from
a living cell to non-living exosome therapy
Sai Kiang
LIM, Institute of Molecular and Cell Biology, Singapore
10:45 –
11:10 Characterization and application
of size-dependent mesenchymal stem cell subpopulations separated by label-free
microfluidics
Yin LU (YI),
Bioprocessing Technology Institute, Singapore
11:10
– 11:25 Selected abstract
Articular
chondrocyte differentiation of fibroblast cells
Yu-Lieh (Ray) LIN1;
Ling YU1; Mingquan YAN1; Ken
MUNEOKA1, Texas A&M
University, US
11:25
– 11:50 Current trends in cartilage
repair in the clinic
James HUI, National
University of Singapore
11:50 –
13:00 BREAK – EXHIBITORS AND SPONSORS
SHOWCASE
Session
9. Costs and Benefits of Cell and Gene Therapies
Chair: Steve OH, Bioprocessing Technology
Institute, Singapore
13:00 –
13:25 Value of CAR-T therapy and access consideration
Jie ZHANG, Novartis,
USA
13:25 –
13:50 Solutions to improve the
productivity of CGT manufacturing
Premkumar JAYARAMAN,
Thermo Fisher Scientific
13:50 – 14:05 Selected
abstract
Generation
of “broad-spectrum” cytotoxic cells with built-in cancer recognition
capabilities of both NK cells
and
γδ T Cells from iPSCs without genetic
modification
Jieming ZENG, CytoMed
Therapeutics Pte Ltd, Singapore
14:05 – 14:20 Selected abstract
Influence of
3D aggregate culture on epigenetic memory and pluripotent state in human
induced pluripotent
stem
cells
Naruchit
THANUTHANAKHUN, Mee-Hae KIM, Masahiro
KINO-OKA,
Osaka University, Japan
14:20 – 14:45 Are the ISCT MSC criteria holding back
clinical translation?
Christopher BRAVERY, Advbiols, UK
14:45– 15:00 The role of impeller design in stirred
tank bioreactors for cell therapy manufacture
Tom WYROBNIK, University
College of London, UK
15:00
– 15:15 Selected abstract
Development
of instability analysis based on critical quality attributes for filling
process of human induced pluripotent stem cells
Adithya NAIR,
Ikki HORIGUCHI, Kazuhiro FUKUMORi,
Masahiro KINO-OKA, Osaka
University, Japan
15:15 – 15:30 BREAK
Session
10. SCSS Dr Susan Lim Outstanding Young Investigator Award Lecture
Chair: Hongyan Wang, Duke-NUS Medical School,
Singapore
15:30
– 16:05 Kidney organoid ---
Reconstructing tissue complexity
Yun XIA, Lee
Kong Chian School of Medicine, Singapore
16:05 END OF DAY 3 & FAREWELL
Jointly Organized by:
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