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TENTative Schedule (subject to changes)


Day 1, 8 December 2021


Welcome Address & MOU Ceremony

 

9:15 – 9:30      Welcome Address (Hongyan WANG (Chair of the Organizing Committee)

                        MOU Ceremony (Ray DUNN, President SCSS & Yoshiki SAWA, President JSRM)

 

Session 1. Advancing Cell Therapies in Japan and Beyond: Session with the Japanese Society for Regenerative Medicine (JSRM)

Chair: Shigeki Sugii, IBN, Singapore

9:30 – 10:05    KEYNOTE LECTURE

Frontier regenerative medicine in cardiovascular area and Overview of JSRM

Yoshiki SAWA, Osaka University, Japan

 

10:05 – 10:30  JSRM: an academic society as an open innovation platform

Kyosuké MANO, The Japanese Society for Regenerative Medicine, Japan           

 

10:30 – 10:55  FZD5 regulates cellular senescence in human mesenchymal stem/stromal cells

                        Yo MABUCHI, Tokyo Medical and Dental University, Japan

 

10:55 – 11:20  Development of human resources of operators in JSRM and current topics for cell manufacturing

                        Masahiro KINO-OKA, Osaka University, Japan

 

 

11:20 – 11:45  iPSCs-based regenerative medicine for spinal cord injury and drug development for ALS

                        Hideyuki OKANO, Keio University, Japan

 

11:45 – 12:10  Establishment of next generation peripheral blood vascular regeneration cell therapy

Rica TANAKA, Juntendo University, Japan

 

 

12:10 – 13:00  BREAK – EXHIBITORS AND SPONSORS SHOWCASE

 

 

Session 2. STEMCELL Technologies Session - Organoids as Tools for Disease Modelling

Chair: Ryan CONDER, STEMCELL Technologies, Canada

 

13:00 – 13:10  Corporate Video presentation

 

13:10 – 13:30  Recent developments and applications using organoids

                        Ryan CONDER, STEMCELL Technologies, Canada

 

13:30 – 13:50  Human pluripotent stem cell-derived pancreatic beta cells for studying diabetes disease mechanisms

                        Adrian TEO, Institute of Molecular and Cell Biology, Singapore

 

13:50 – 14:10  The use of human induced pluripotent stem cell-derived cerebral organoids to investigate the role of apolipoproteins e in Alzheimer's Disease

                        Damian HERNANDEZ, The University of Melbourne, Australia

 

14:10 – 14:30  3D midbrain organoids: A 3rd dimension to investigate PD pathogenesis

                        Alfred SUN, Genome Institute of Singapore

 

 

14:30 – 14:45  BREAK

 

 

Session 3. In-vitro models of Health and Disease

Chair: Ray Dunn, Lee Kong Chian School of Medicine, Singapore

 

14:45– 15:10   ALS motor neurons exhibit hallmark metabolic defects that are rescued by SIRT3 activation

Shi Yan NG, Institute of Molecular and Cell Biology, Singapore

 

15:10 – 15:35  Molecular underpinning of vascular endothelial dysfunction in polypoidal choroidal vasculopathy

Christine CHEUNG, Lee Kong Chian School of Medicine, Singapore

 

15:35 – 16:00  Defining essential enhancers for pluripotent stem cells using a features-oriented CRISPR-Cas9 screen

Jonathan LOH, Institute of Molecular and Cell Biology, Singapore

 

16:00 – 16:15  BREAK

 

16:15 – 16:40  Chromatin wiring and re-wiring in the heart

Roger FOO, Genome Institute of Singapore

 

16:40 – 17:05  Modeling of endothelial dysfunction using hiPSCs reprogrammed from patients with

T2DM

Lei YE, National Heart Centre, Singapore

 

17:05 – 17:20  Selected abstract

Stem cell differentiation into mature pancreatic islets for diabetes cell therapy

                        Punn AUGSORNWORAWAT and Jeffrey R MILLMAN, Washington University in St. Louis, US

 

17:20 – 17:45  Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain

Aoife MURRAY, Queen Mary University of London, UK

 

17:45 – 18:00 BREAK

 

 

18:00 – 19:00  Session 4. Live Fire-talks 1

 

Moderator: Ray DUNN, LKCM, Singapore

 

Presenters:

Natasha NG, IMCB, Singapore

Avinanda BANERJEE, inStem, India

Jun Wei CHAN, IMCB, Singapore

Tong Ming LIU, IMCB, Singapore

Durga Shankar SHARMA, University of Hyderabad, India

Alan LAM, Bioprocessing Technology Institute, Singapore

 

 

19:00               END OF DAY 1

 

 


Day 2, 9 December 2021


Session 5. Neural Stem Cells and Neurological Disorders

 

Chair: Hongyan WANG, Duke-NUS Medical School, Singapore

 

9:00 – 9:35      KEYNOTE LECTURE

Postnatal neural stem cells and prospects for neuronal replacement

Arturo ALVAREZ-BUYLLA, University of California San Francisco, USA

 

9:35– 10:00     Differential metabolic profiles confer resistance in glioblastoma therapies: stratification goals and implementation

Carol TANG, National Neuroscience Institute, Singapore

 

10:00 – 10:25  Channel dysfunction underlying epilepsy of Angelman Syndrome

Qiang YUAN, Duke-NUS, Singapore

 

10:25 – 10:40  Selected abstract

Msps governs acentrosomal microtubule assembly and reactivation of quiescent neural stem cells

Qiannan Deng, Duke-NUS Medical School, Singapore

 

10:40 – 10:55  BREAK

 

10:55 – 11:20  Neural stem cells and neurological disorders

Louise CHENG, Peter McCallum Cancer Centre, Australia

 

11:20 – 11:45  In-vitro modeling of dementia using 3d techniques

Li ZENG, National Neuroscience Institute, Singapore

 

11:45 – 12:10  Mechanisms that regulate brain stem cell proliferation in the normal brain and brain tumors

Derrick ONG, National University of Singapore

 

 

12:10 – 13:00  BREAK – EXHIBITORS AND SPONSORS SHOWCASE

 

 

Session 6. Deconstructing and Reconstructing Organogenesis

 

Chair: Christine CHEUNG, Lee Kong Chian School of Medicine, Singapore

 

13:00 – 13:25  Deciphering the aetiology of pancreatic hypoplasia in Mitchell-Riley Syndrome

Ray DUNN, Lee Kong Chian School of Medicine, Singapore

 

13:25 – 13:50  Surgical transplantation of human RPE stem cell derived RPE (hRPESC-RPE) monolayers into non-human primates with immunosuppression

Xinyi SU, Institute of Molecular and Cell Biology, Singapore

 

13:50 – 14:15  Stem cell derived liver organoids

Winston CHAN, Genome Institute of Singapore, Singapore

 

14:15 – 14:30  Selected abstract

A 3D-printed GelMA scaffold assembly for the co-culture of human endothelial cells and beta cells

Alvin Soetedjo, Institute of Molecular and Cell Biology, Singapore

 

14:30 – 14:45  BREAK

 

14:45 – 15:10  Biomimetic materials in medicine and beyond

Javier GOMEZ FERNANDEZ, Singapore University of Design & Technology

 

15:10 – 15:35  Using human pluripotent stem cells to understand airway basal cell development

Kim Jee GOH, Lee Kong Chian School of Medicine, Singapore

 

15:35 – 16:00  Infection and immunity of SARS-CoV-2 infections: diagnostics & therapies for COVID-19

Lisa NG, Singapore Immunology Network

 

 

16:00 – 16:30  BREAK

 

 

16:30 – 17:30  Session 7. Live Fire-talks 2

 

Moderator: Christine CHEUNG, LKCM

 

Presenters:

Matias AUTIO, Genome Institute of Singapore

Parvathi CHANDRAN, Regrow Biosciences, India

Wei Xuan TAN, IMCB, Singapore

Yisheng CUI, Osaka University, Japan

Patrick FOONG, Western Sydney University, Australia

Rubina SHAKYA, Mahidol University, Thailand

Lillian LIM, IMCB, Singapore

 

17:30               END OF DAY 2

 

 

 


Day 3, 10 December 2021


Session 8. Cell-based and Immuno Therapies

            Chair: Simon COOL, Institute of Molecular and Cell Biology, Singapore

9:30 – 9:55      Optimising blood stem cell transplants through cellular engineering

William HWANG, National Cancer Centre, Singapore

 

9:55 – 10:20    From SARS to COVID-19 in Singapore: The role of virus-specific T-cells

Antonio BERTOLETTI, Duke-NUS, Singapore

 

10:20 – 10:45  MSC Regenerative Medicine from a living cell to non-living exosome therapy

Sai Kiang LIM, Institute of Molecular and Cell Biology, Singapore

 

10:45 – 11:10  Characterization and application of size-dependent mesenchymal stem cell subpopulations separated by label-free microfluidics

Yin LU (YI), Bioprocessing Technology Institute, Singapore

 

11:10 – 11:25  Selected abstract

Articular chondrocyte differentiation of fibroblast cells

Yu-Lieh (Ray) LIN1; Ling YU1; Mingquan YAN1; Ken MUNEOKA1, Texas A&M University, US

 

11:25 – 11:50  Current trends in cartilage repair in the clinic

James HUI, National University of Singapore

 

 

11:50 – 13:00  BREAK – EXHIBITORS AND SPONSORS SHOWCASE

 

 

Session 9. Costs and Benefits of Cell and Gene Therapies

                       

                        Chair: Steve OH, Bioprocessing Technology Institute, Singapore

 

13:00 – 13:25  Value of CAR-T therapy and access consideration

Jie ZHANG, Novartis, USA

 

13:25 – 13:50  Solutions to improve the productivity of CGT manufacturing

Premkumar JAYARAMAN, Thermo Fisher Scientific

 

13:50 – 14:05  Selected abstract

                        Generation of “broad-spectrum” cytotoxic cells with built-in cancer recognition capabilities of both NK cells

                        and γδ T Cells from iPSCs without genetic modification

Jieming ZENG, CytoMed Therapeutics Pte Ltd, Singapore

 

14:05 – 14:20  Selected abstract

                        Influence of 3D aggregate culture on epigenetic memory and pluripotent state in human induced pluripotent

                        stem cells

Naruchit THANUTHANAKHUN, Mee-Hae KIM, Masahiro KINO-OKA, Osaka University, Japan

 

14:20 – 14:45  Are the ISCT MSC criteria holding back clinical translation?

Christopher BRAVERY, Advbiols, UK

 

14:45– 15:00   The role of impeller design in stirred tank bioreactors for cell therapy manufacture

Tom WYROBNIK, University College of London, UK           

 

15:00 – 15:15  Selected abstract

                        Development of instability analysis based on critical quality attributes for filling process of human induced pluripotent stem cells

Adithya NAIR, Ikki HORIGUCHI, Kazuhiro FUKUMORi, Masahiro KINO-OKA, Osaka University, Japan

 

 

15:15 – 15:30  BREAK

 

 

Session 10. SCSS Dr Susan Lim Outstanding Young Investigator Award Lecture

                       

                        Chair: Hongyan Wang, Duke-NUS Medical School, Singapore

 

15:30 – 16:05  Kidney organoid --- Reconstructing tissue complexity

Yun XIA, Lee Kong Chian School of Medicine, Singapore

 

 

16:05               END OF DAY 3 & FAREWELL


Jointly Organized by:
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