"Modelling complex diseases using human induced pluripotent stem cells"
ABSTRACT We use patient induced pluripotent stem cells to model complex human neurodegenerative conditions. By combining stem cell cultures, multiple -omics and functional analysis approaches, we have established models of age-related macular degeneration and glaucoma, which will be described in this seminar.
BIO Alice Pébay obtained a PhD in Neurosciences from the University of Paris VI in 2001 and subsequently joined Professor Martin Pera at Monash University (Australia) to undertake research on human pluripotent stem cells. She then continued her research in this area at the University of Melbourne where she commenced in 2007. Alice’s team aims to use patient specific pluripotent stem cells to model neurodegenerative diseases of the eye. Alice has a proven track record in generating iPSCs and differentiating them into various cell types for disease modelling including those affecting the eye. Alice and her collaborators have pioneered the use of automation for human pluripotent stem cell research in Australia, enabling the streamlining generation and maintenance of iPSC-derived cells from hundreds of patients. Alice was awarded a National Health & Medical Research Council (NHMRC) Career development Fellowship in 2012, subsequently an Australian Research Council Future Fellowship in 2014 and is now a NHMRC Senior Research Fellow. Alice is the primary inventor of three granted international patents related to stem cell technology.