Sing Yian CHEW Nanyang Technological University Understanding & Directing Cell Fate Using Biomimetic Scaffolds
Abstract The extracellular matrix plays crucial roles in dictating cell fate and tissue regeneration. Physical signals like matrix topography and compliance affect cellular response. Combined with biochemical signals from drugs, growth factors and nucleic acids, synergistic effects on directing cell phenotypic changes and tissue regrowth are often seen. Here, we will share our approaches towards designing bio-mimicking constructs to direct neural cell fate.
Bio Sing Yian CHEW is known for her contributions in designing biomimetic scaffolds to understand and control cell fate. Her most significant contribution is in the field of scaffold-mediated delivery of gene-silencing and biomimicking physical signals for neural tissue regeneration and remyelination. She is an Associate Editor at ACS Applied Materials & Interfaces. She serves as the editorial board member of Biomaterials, Experimental Neurology, Tissue Engineering, Journal of Tissue Engineering, etc..
Thuy TramDANG Nanyang Technological University TBA
Abstract Transplantation of cellular therapeutics holds great promise as a long-term therapy to replace diminished pancreatic insulin production and improve glucose regulation to potentially benefit more than 500 million diabetic patients worldwide. Encapsulation of insulin-secreting therapeutic cells in immuno-isolating hydrogels prior to transplantation protects them from host immunological attack without the needs for immunosuppressants which are often associated with adverse side effects. In this talk, we will discuss several drug delivery and tissue engineering strategies that have been adopted to improve survival and functional performance of immuno-isolated islets towards enhancing their efficacy in diabetes management.
Bio Thuy Tram DANG is Assistant Professor at the School of Chemical and Biomedical Engineering and a Fellow of the Ageing Research Institute for Society and Education (ARISE) at Nanyang Technological University (NTU), Singapore. Dr Dang received her B.Sc degree from the University of Illinois, Urbana-Champaign (USA) and Ph.D. degree from Massachusetts Institute of Technology (USA), both in Chemical Engineering. She also conducted her postdoctoral training as a Controlled Release Society fellow at Brigham and Women’s Hospital, Harvard Medical School (USA). Prior to joining NTU, she was a Senior Research Fellow at the Institute of Medical Biology, Agency for Science, Technology & Research (A*STAR), Singapore. She was the recipient of the A*STAR Singapore National Science Fellowship, MIT Edward Clark Presidential Fellowship and the Controlled Release Society Sung Wan Kim postdoctoral fellowship. Dr Dang has served as the Associate Editor of the journal Drug Delivery and Translational Research and a board member of Controlled Release and Encapsulation Network (CoRENET), Singapore. Dr Dang’s research leverages fundamental understanding of the interaction between biomaterials and the immune systems to design novel immuno-modulatory biomaterials and therapeutic delivery systems for the treatment of diabetes and inflammatory diseases.