15 November (Day 3)
Session
5. Immuno & Gene Therapy
Chair:
John Connolly, Institute of Molecular and Cell
Biology, Singapore
09:00-09:25 Virus specific T cells as
platform for solid tumor immunotherapy
John
Connolly, Institute of Molecular and Cell Biology, Singapore
09:25-09:40 Short talk: FOXP3 gene editing towards
autologous stem cell therapy to cure IPEX Syndrome
Esmond Lee, Stanford
University, USA
09:40-10:05 Gamma Delta T cells for anti-cancer
immunotherapy
Shu Wang, National University of Singapore,
Singapore
10:05-10:35 MORNING
TEA BREAK
10:35-11:00 T cell therapy as a localized modulator of
tumor immune environment
Antonio Bertoletti, Duke-NUS Medical School, Singapore
11:00-11:15 Short talk: Characterisation of novel human
genomic safe harbours for transgene expression
Matias Autio, Genome
Institute of Singapore, Singapore
11:15-11:40 Expansion of human tumor infiltrating γδ T cells for cancer therapy
Michael Lotze, University of Pittsburgh, USA
11:40-13:15 LUNCH BREAK
Session
6. Advanced Technologies
Chair:
Karl Tryggvason, Duke-NUS Medical School, Singapore
13:15-13:35 The Science of stem cell therapy – parameters
affecting dosing and efficacy
Andre van Wijnen, Mayo Clinic, USA
13:35-13:50 Short
talk: Metformin affects pancreatic differentiation from human embryonic stem
cells
Adrian Kee Keong Teo, Institute of
Molecular and Cell Biology, Singapore
13:50-14:10 Cellular
therapy for burns/skin injuries: Laminin-based epidermal keratinocytes culture
system in xeno-free and chemically defined condition
Monica Tjin, Duke-NUS Medical School,
Singapore
14:10-14:30 Minimizing immunogenicity of iPS cells by
custom disruption of HLA genes utilizing CRISPR-Cas9 genome editing: Towards 2nd
generation iPS cell stock for cost-effective cell therapy
Akitsu
Hotta, Kyoto University, Japan
14:30-15:00 AFTERNOON TEA BREAK
15:00-15:20 Manufacturing cell therapies with predictive
therapeutic outcomes: Case studies in critical quality attributes for stem
& stromal cell therapies
Krystyn
J. Van Vliet, MIT and Singapore-MIT Alliance for
Research & Technology
15:20-15:40 Astrocytes derived from spinal muscular
atrophy (SMA) patients are hyper-reactive and exacerbate neuronal degeneration
Lawrence
Stanton, Qatar Biomedical Research Institute, Qatar
15:40-16:00 Endothelial instability predisposes ischemic
stroke patients to recurrent vascular events
Christine Cheung, Nanyang Technological University, Singapore
16:00-16:15 Short talk: Retina specific laminins model inter-photoreceptor matrix to
drive differentiation of photoreceptors from human pluripotent stem cells
Hwee Goon Tay, Duke-NUS Medical
School, Singapore
16:15-16:45 DR SUSAN LIM AWARD FOR OUTSTANDING YOUNG
INVESTIGATOR 2019 LECTURE (Introduction: Ray Dunn, President SCSS)
Global translation in early embryos and embryonic stem cells depends on
the essential transcription factor PRDM10
Daniel Messerschmidt, Institute of Molecular and
Cell Biology, Singapore
16:45-17:00 AWARDS, CLOSING REMARKS & FAREWELL
END
OF DAY 3 & END OF SYMPOSIUM
Jointly Organized by:
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