13 November (Day 1)
Welcome & Opening of Symposium
8:30 – 8:45 Welcome Address, Shigeki
Sugii, Simon Cool, Co-Chairs of Organizing Committee
Introduction to the Singapore Cell Therapy
Manufacturing Programmes
8:45 – 8:55 Allogeneic
Stem Cell Manufacturing (ASTEM)
Simon Cool, Institute
of Medical Biology, A*STAR
8:55 – 9:05 Integrated Manufacturing
Programme for Autologous Cell Therapy (IMPACT)
John Connolly, Institute
of Molecular and Cell Biology, A*STAR
9:05 – 9:15 Critical Analytics for Manufacturing
of Personalized-Medicine Programme (CAMP)
Krystyn van Vliet, MIT and Singapore-MIT
Alliance for Research & Technology
9:15 – 10:00 KEYNOTE LECTURE (Chair: Steve Oh, BTI,
Singapore)
Genetically engineered immunity for cancer: the
development and global regulatory approvals of chimeric antigen receptor (CAR)
T cells and what’s coming next
Bruce Levine, University
of Pennsylvania, USA
Session 1. Stem Cell Therapy
Chair: Simon Cool, Institute of Medical Biology,
Singapore
10:00-10:20 Long term
clinical outcomes of stem cell therapy in cartilage repair: Are we ready for
the next step?
Francis KL Wong,
Duke-NUS-Medical School, Singapore
10:20
– 10:50 MORNING TEA BREAK
Session 1 cont. Stem Cell Therapy
10:50 – 11:10 Establishing the National Cell Therapy
Program for process development and clinical manufacturing of cell & gene
therapy products in Singapore
Lip Kun Tan, National University
Hospital, Singapore
11:10 – 11:30 Stem cell expansion of cord blood graft” vs
“bridging support with 3rd party hematopoietic stem/progenitor cells
Satoshi Takahashi, University
of Tokyo, Japan
11:30 – 11:45 Short talk: The Influence of
the amniotic fluid stem cell secretome on
cardiomyocyte cellular behaviour
Marek Kukumberg, National
University of Singapore
11:45 – 12:00 Short
talk: Long-term culture of human pancreatic progenitors: an alternative source
of insulin-secreting beta cells
Jamie Trott, Institute of Medical Biology,
Singapore
12:00 – 12:20 Cardiovascular progenitors for heart regeneration in preclinical
models
Lynn Yap, Duke-NUS
Medical School, Singapore
12:20 – 12:35 Short
talk: Generation of induced motor neurons (iMNs) from
human fibroblasts for cell therapy in spinal cord injury model
Hyunah Lee, Ulsan National Institute
of Science and Technology, Korea
12:35 – 12:55 Softer,
faster, better! – Substrate mechanics drives superior somatic cell
reprogramming outcomes
Justin Cooper-White, Australian Institute for Bioengineering and Nanotechnology, Australia
12:55
– 14:15 LUNCH BREAK
Session 2. Manufacturing and Quality Control
Co-Chairs:
Anthony Davies, Dark House Consulting, USA
Shin Kawamata, Foundation for Biomedical Research &
Innovation, Japan
14:15 – 14:35 Effective
& cost-effective, but unaffordable? The future of cell and gene therapy
Anthony Davies, Darkhouse Consulting, US
14:35 – 14:55 Bringing
immune cell therapies to patients, innovative solutions for CAR T
manufacturing, enabling scalability and cost reduction
Ohad Karnieli, ATVIO, Israel
Drew
Titmarsh, Scaled Biolabs, USA
15:15 – 15:35 Future of transfusion medicine – Human induced pluripotent
stem cells derived blood?
Jaichandran Sivalingam, Bioprocessing Technology Institute, Singapore
Tong Ming Liu, Institute of
Molecular and Cell Biology, Singapore
15:50
– 16:10 Nature
inspired DMSO-, protein-, serum-free and chemically defined biopreservation
solution, new horizon of precision in cell manufacturing and processing
Mark Kline, X-Therma, USA
16:10
– 16:40 AFTERNOON TEA BREAK
16:40 – 17:00 In process
monitoring for mass production of pluripotent stem cells
Shin Kawamata, Foundation for Biomedical Research
& Innovation, Japan
17:00 – 17:20 Automated cell
expansion: Trends & outlook of critical technologies
May-Win
Naing, Singapore Institute of Manufacturing Technology, Singapore
17:20 – 17:40 Regeneus’ novel allogeneic stem cell
platform for Osteoarthritis
Charlotte Morgan, Regeneus, Australia
17:40 – 17:55 Short
talk: Sub-confluent culture of human mesenchymal stem cells on biodegradable
polycaprolactone microcarriers enhances bone healing of rat calvarial
defect
Alan Tin-Lun Lam, Bioprocessing Technology Institute, Singapore
17:55 – 18:40 Panel discussion
Panellists: C Morgan,
MW Naing, O Karnelli, M Kline, D Titmarsh
Moderators: A. Davies and S. Kawamata
END OF DAY 1
Jointly Organized by:
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